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There are two types of the people in the world. Some are The people who give up because of small problems in life which they believe as the greatest problem in world.The others are the ones who fought against the real greatest problems and achieved their dream success.The men who give up would be tired of the sea which roars.The other believes that “A smooth sea never made a skillful sailor“.Even The Airplane flies against the wind , not with it.So , here i will show you some magic recipe of success and some life stories. Learn from them and be the skillful sailor.I welcome you to my Motivational Blog Way4Vision

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Change Your History Make Your Future Bright

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Having A Dark Past Doesn’t Mean That You Can’t Have A Bright Future…….Do you have a dark past .ever worried about how it would affect your future.Then Forget it..It’s Time to Rewrite Your History.

 

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The Light Has importance only if there is darkness.Your Future wants to be the light which Annihilates The darkness of Your Past.You Must Have Heard Of Robert Downey Jr.The Ironman. In childhood He was surrounded By drugs(marijuana and other drugs) and his own Father Gave it to him.He was Exhausted by drugs and life for him was really hard.He was Ended up with some of cases and in jail.Later His father regretted to give him drugs..Now He Has Changed His story to a success. For three consecutive years from 2012 to 2015, Downey topped the Forbes list of Hollywood’s highest-paid actors, making an estimated $80 million in earnings between June 2014 and June 2015.Now he is the most Favorite actor of millions…

 

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So Past Is not a measurement for your success.Hard work and willpower is…Even The most beautiful Flowers Have roots in the dirt.So Don’t Worry About Your Past.If You Follow This “Past would be A Story, Present Would be Struggle ,And Your Future will Be A History”

Wait For My new Blog.It’s On the way.So it’s Ahmed Nishthak Signing Off For Today

Thankyou

 

The Art Of Letting Go

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Some problems in life are unsolvable…Maybe it’s a relationship….Always learn to move on.let go of the bitter past,learn the lessons,and let go of the memories…You know it’s something hard…Sometimes it hurts…But you can’t always find a solution for all the problems.But you know , Letting go is also a lesson, where we learn that that is not meant for us..

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  1. Moving on

Moving on is not a negative process it’s all positive ….It’s a process of letting go off your sorrows starting a new life…And forgive and forget the past which only gives us sorrow….There would be moments which you are missing too much….But it’s the law of life…Believe it…

The present life would be more frustrating for you…The profusion of memories,The bitterness…It sucks….How much time would you spend for fixing an non fixable thing..It’s mere useless..

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Try to smile…Try to see good in every situation…Try to be positive and forget….It’s life , Here it is always like this

“Don’t allow your past Blackmail your present with ruining your beautiful future “

2.Letting Go of your safe zones

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Safe zones is always a dangerous place to stand …Always take a move…Letting go of your safe zones will gain you only greater…Staying always in safe zone means you are a coward…Are you…Take up the step…Sometimes it’s hard to move on but once you move on you’ll realize that it was the best decision you ever made….

FAREWELL TO THE LEGEND

FAREWELL TO THE LEGEND

I was quite busy all the days….so i couldn’t write my blog nearly for one year…..I apologize….BUT, Today iam standing in front of you with a deep heartbreak. The man who won over the fate has passed away…..

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The extraordinary journey Started from 8th January 1942 has came to an end….It’s really a heartbreaking news…. Hawking was the representative of a determined person who never gives up….His contributions to the science was really great….As A Human Hawking inspired us in different aspects of life…..Life may seem difficult to him but he just nailed it….Hawking was the representative of the determination , strength, and willpower .He was just an amazing guy….I was a great fan of him…He is a true legend….Farewell to the man who never gave up……

Anthony Robels – The Unstoppable

Don’t You know the story of Anthony Robels. Who proved the whole world that excuses are just a elope from your life.Excuses never pave the path to success,But hard work does.Here, after a long break from my blog activities i show you the man who paved the path of success through hard work, Determination, and failures…..

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It was 1988 and it became a stressful day for judy robles .She was pregnant and it was the delivery date.The 16 year old judy gave birth to a cute looking child.But…….They realized that the kid was born without one leg…..Her Father looked disappointed.Judy Cried a lot but then she told to herself “To Me He Is Perfect”. That decision changed their lives..Now he is the most known american wrestler.And He Is ANTHONY ROBELS-The Unstoppable.

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Throughout his childhood he remained a desire to be exactly like other children.But he was unable to do the most simple things like changing the clothes or getting ready to school .In the early age he took off his prosthetic leg and hid it from his mother judy. His brother once told; He would play basketball and football with us.I often selects him to my team because he usually wins.”

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He could do anything. It never occurred to him that he couldn’t.

His mother wouldn’t stand for it. “Knowing that he was different,” Judy Robles says, “it was kind of like my job as his mom that he never felt it. Maybe I overdid it in a way. Maybe I wanted him to be so normal that I kind of pushed him.”

His innocence was shattered in the third or fourth grade. That’s when he first noticed. When he saw that not everyone thought he could do anything, the way his family always did. It shook him, and he tried to not stand out too much, the way every kid does, at some point in his or her life.

But it wasn’t something he could fix with the right sneakers or cooler clothes.

Nicolas would jump in front of him, trying to take the bullets. He would stare daggers at anyone whose glance lingered just a beat too long.

His family — his parents, three younger brothers, a little sister — they always saw the stares.

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Anthony started wrestling in the eighth grade and accomplished most in 2011 and 2012. Anthony Robles has spent his entire career in the state of Arizona. During his wrestling career Anthony Robles had an outstanding season and achieved several awards but he did not stop after that. Anthony became a motivational speaker to help other people who face the same problems he did. Anthony Robles possesses many traits that define him as a hero, but the ones that qualify the most are how persistent he is, and the fact the he is unstoppable.

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anthony’s first wrestling match during his freshman year definitely didn’t prove anything to the world about what a good wrestler he was but it did make a very clear statement to all who witnessed as to how strong his mind was. As was customary for the team, they ran out into the gymnasium and circled the mat. Anthony was right there with them, hopping on one leg…
The rest of that first season wasn’t a lot better for Anthony. He continued to get beat far more often than he won. At some point Anthony latched on to Chris Freije, one of Anthony’s high school teammates. Chris was one of the best wrestlers on the team. As was the code on the team, Chris obliged Anthony and of course dominated him every time.
He had finally made a believer of his teammates and his coaches with his dedication, commitment and “unstoppable” attitude. His coaches started to focus on strategies and techniques Anthony could use to his advantage that fit his body type. By his junior year, Anthony had become the guy everyone wanted to work and train with. In his last two years of high school Anthony would win two state wrestling championships and his senior year was a national champion in his weight class. His high school record is a very impressive 129-15… 48-0 in his last two seasons.

Anthony Proves, The Unstoppable

He went on to become one of the most accomplished wrestlers in history.

Despite Robles’ great high school success none of his top choices for college—Iowa, Oklahoma State, and Columbia—recruited him, likely because of his missing leg .Robles redshirted as a freshman at Arizona State University, and finished 6th in the 2006 FILA Junior World Championships in the 55 kg Freestyle Wrestling category.He started his collegiate wrestling career in 2007-08, where he was nationally ranked and finished the year with a record of 25-11, falling just short of being named as an All-American. In his second competitive year as a collegiate wrestler (2008–2009) Robles earned All-American Honors, finishing the year 29-8, winning the Pacific-10 Conference Championship at 125 pounds and finishing fourth in the NCAA Championship’s 125 pound weight class tournament. In 2009-10, Robles again earned All-American honors, finishing seventh in the NCAA 125 pound weight class, going 32-4 on the season, and repeating as the Pac-10 125 pound wrestling champion.

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In Robles’ final year of eligibility (2010–11), he went undefeated, going 36-0 on the year, becoming a three-time Pac-10 champion (defeating Jason Lara from Oregon State in the final, and a national champion, beating the defending 125-pound NCAA Champion, Iowa’s Matt McDonough, 7-1 in the final. For his efforts, Robles was voted the Tournament’s Most Outstanding Wrestler.

The 5’8″ Robles concluded his Arizona State wrestling career with a record of 122-23, a three-time Pac-10 wrestling champion as well as a three-time All-American. Robles ranks 8th for most match wins by an Arizona State wrestler.

  • 2011 NCAA Champion
  • 2011 NCWA Outstanding Wrestler of the Tournament
  • Four-time NCAA All-American
  • Four-time NCAA Qualifier
  • Three-time PAC 10 Conference Champion
  • Four-time PAC 10 Conference Finalist
  • Finished 8th in career victories at 122
  • Finished his 2011 season at ASU with a perfect 36-0 season

In January 2012, Robles was presented the 2011 Most Courageous Athlete Award by the Philadelphia Sports Writers Association

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we are the people who give up because of some excuses or some failures.For that kind of people i present this Unstoppable story.The story of the UN-DEFEATED. The great story of ANTHONY ROBELS – THE UNSTOPPABLE.

With all of the respect

This Is AHMED NISHTHAK signing off…..

From Blindness To Greatness-Marla Runyan

Marla Runyan developed Stargardt’s Disease at the age of 9. This left her blinded for the rest of her life. However, she took the stick of courage and emerged out as a national champion 3 times in women’s 5000-metres race. She won medals and accolades at various national and international sporting events.And become the inspiration for centuries.Here is the wonderful story 

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Disease

As usual i will tell some words about the disease first.

 

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stargardt disease, or fundus flavimaculatus, is the most frequent form of inherited juvenile macular degeneration. Stargardt causes progressive vision loss usually to the point of legal blindness. Several genes are associated with the disorder. Symptoms, mainly central vision loss, typically develop before age 20 (median age of onset: ~17 years old), and also include wavy vision, blind spots, blurriness, impaired color vision, and difficulty adapting to dim lighting (dark adaptation delays).

Stargardt is often used to refer to any juvenile macular dystrophy; however, it properly refers to atrophic macular dystrophy with yellow, poorly-defined flecks surrounding the macula in the retinal pigment epithelium.

Signs and symptoms

Patients with Stargardt disease usually develop symptoms in the mid-first to the late second decade of life, with age of onset which can be as early as ~6 years of age. The main symptom of Stargardt disease is loss of visual acuity, uncorrectable with glasses, which progresses and frequently stabilizes between 20/200 and 20/400.Other symptoms include wavy vision, blind spots (scotomata), blurriness, impaired color vision, and difficulty adapting to dim lighting (delayed dark adaptation). The disease sometimes causes sensitivity to glare; overcast days offer some relief. Vision is most noticeably impaired when the macula (center of retina and focus of vision) is damaged, leaving peripheral vision more intact. Generally, vision loss starts within the first 20 years of life.

Examination with an ophthalmoscope shows few notable findings in the early stages of the disease. Eventually, however, an oval-shaped atrophy with a horizontal major axis appears in the retinal pigment epithelium, and has the appearance of beaten bronze, along with sparing of the area surrounding the optic disc (peripapillary sparing).Techniques such as fundus autofluorescence (FAF), Optical Coherence Tomography (OCT), or less frequently fluorescein angiography, can detect early signs before they are visible ophthalmoscopically.

Treatment

Currently, there is no treatment for the disease. However, ophthalmologists recommend wearing sunglasses and hats outdoors and blue-light blocking glasses when exposed to artificial light sources, such as screens and lights.Tobacco smoke and second-hand smoke should be avoided. Animal studies also show that high doses of vitamin A can be detrimental by building up more lipofuscin toxin. Dietary non-supplemental vitamin A intake may not further the disease progression. Clinical trials are being conducted with promising early results. The trials may one day lead to treatments that might halt, and possibly even reverse, the effects of Stargardt disease using stem cell therapy, gene therapy, or pharmacotherapy.

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The Argus retinal prosthesis was successfully fitted to a 67-year-old women in Italy at the Careggi Hospital in Florence by Professor Stanislao Rizzo in 2016. The patient had a very advanced stage of Stargardt’s disease, and a total absence of peripheral and central visual fields.

The Story Of The Blindness To Greatness

Marla Lee Runyan (married name Lonergan, born January 4, 1969) is an American track and field athlete, road runner and marathon runner who is legally blind. She is a three-time national champion in the women’s 5000 metres.Runyan was born in Santa Maria, California.

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She is the holder of three United States 1,500 meter titles, she is ranked number one in the United States 5 km run and the marathon in 2002. In addition to that, she is a two-time Olympian, a USA Indoor 3,000 meter champion, and came in tenth in the 1,500 meter at the 1999 World Outdoor Championship. Marla holds records in the 20 kilometer Road, All-Female marathon, 500 meter and Heptathlon. All of these accomplishments would be incredible for any normal athlete, but Marla Runyan isn’t any normal athlete. Marla Runyan is legally blind, so all of these titles make Marla one of the most outstanding runners of our time. Marla Runyan was born on January 4, 1969 in Santa Maria, California. She was born into a family consisting of her father, mother, and her older brother Grady.

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Marla wasn’t diagnosed to be blind with Stargardt’s until she was nine years old in 1978. Her doctors had very low expectations for her future, predicting that she would never get above a “C” in school, learn to drive, or go to college. At that time, she was very active in soccer and gymnastics, but eventually had to drop them when her vision made it hard for her to see the soccer ball. She soon picked up running and became very dedicated. She continued running and competing in the Heptathlon, 200m dash, high jump, hurdles, long jump, javelin throw, and 800m run throughout her high school years and during college at San Diego State. She received a degree in Education of the Deaf at San Diego State University and one in Education of Deaf-Blind Children in 1994.

Then, Marla moved to Eugene, Oregon, so she could be closer to her trainers. After a lot of intense training, she was able to place 10th in the Heptathlon at the Olympic Trials in 1996. By 1999, she was ranked 2nd in the USA by T&FN and had come in 1st at the Pan Games by one hundredth of a second during an exciting race. Also, she came in 10th at the World Outdoor Championship for the 1,500 meters.

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In 2000, Marla became the first legally blind American to compete in the Olympics, when she placed eighth in the 1500m and had the highest finish for an American female in the race. Marla also competed in the Carlsbad 5000 Road Race and placed 4th at her first try at long distance.

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Since 2001, Marla has served as the first ambassador for Perkins School for the Blind. She has given many speeches about being blind to the public. Also in 2001, Marla broke the American indoor 5000m record at the New York City Armory, running 15:24 on February 18. In 2002, Marla was the USA Outdoor 5k champion for the second time (she also was in 2001).

Marla became interested in running long distance as well as middle distance, and also competed in the Boston Marathon where she placed 5th. The next year, when it was time for the Olympics, Marla placed 9th in the 5000 meters. Along with the Olympics, Marla kept her title of USA 5000m Outdoor Champion for the third year.

2005 was a joyful year for Marla Runyan, for she had her first child with her husband and coach, Matt Lonergan, on September 1. After taking a break from running to take care of her daughter, Marla amazed many when, in 2006, she bounced back into her career and set a personal record in the 10000 meters with a time of 32 minutes and 11.92 seconds. Despite having her sight being about 20/300 in her left eye and 20/400 in her right eye, Marla has passed all expectations to become extraordinary!

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Being the first legally blind American to compete in the Olympics, Marla Runyan demonstrates signs of heroism for many people who are visually impaired. Also, she has inspired many people who don’t have an impairment. She is an inspiration to many because she has overcome the difficulties of her disability. Plus, she has proven to the world how strong she is, both physically and mentally. Many other people with disabilities have followed her lead and have done things they were always told they could never do. She is living proof that it doesn’t matter if you are different from others to succeed!

Marla has shown an enormous amount of strength, determination, caring, and perseverance throughout her life. She demonstrated strength as she ran many different races, including marathons. And she had the strength to not give in when she was diagnosed with Stargardt’s disease. She also proved how determined she was to lead a normal life and to continue being an athlete despite her impairment. Marla Runyan has shown how caring she is by educating the public as an ambassador for Perkins School for the Blind. Marla should be proud of what a positive role model she is!

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These days, Marla resides in Eugene, Oregon, with her husband, daughter, and dog. Marla Runyan is still running, but her main priority is her daughter, Anna. She wants to make sure Anna has the best childhood possible. When she is not taking care of her daughter, she is training for upcoming races. She is currently focusing on training for marathons more than anything else. One of her most recent races was the Twin Cities Marathon. In this race, she placed 1st in her division.

Unfortunately, Runyan’s vision worsens as time passes.  She is no longer able to see the large “E” on the eye exam chart; her vision is measured at 20/400 in both eyes.  However, Runyan has not allowed her worsening condition to affect her career.  She plans to continue competing in running events.  In 2001, she co-wrote and published her autobiography, No Finish Line:  My Life As I See It.  Marla currently resides in Eugene, Oregon, with her husband and coach Matt Lonergan, whom she married in August 2002.  Marla and Matt recently became parents for the first time when her daughter, Anna Lee Runyan Lonergan, was born on September 1, 2005.

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She is the one who fought against the fate..i recommend this heroic story to the ones who don’t give up…..Marla’s life teaches us to never give up. if someone says something is impossible, it doesn’t mean that it can’t be done. Instead of giving up, Marla focuses on what she can do, not what she can’t. She put no limitations on herself as to what she could do, and because of this, she was able to work her way to the top. She has said, “I don’t consider it to be any sort of disability on the track, honestly, I don’t think of it at all. It’s a condition I’ve had for so many years, that as far as I’m concerned, the way the track looks to me is the way the track looks to everybody else.” I admire her because of her determination and how she follows her dreams. She inspires all to not give up, even if things don’t go as planned.

 

 

The Most Beautiful Woman On Earth-Lizzie velaquez

“The world’s most ugliest woman” she once faced such words from millions…….But she fought and fought.And she became the world’s most beautiful woman in the world. Apj has said “beauty is not in face it’s in your heart” And the successful story,here i begin;

 

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Elizabeth AnnLizzieVelásquez was born to Rita and Guadalupe Velásquez, Lizzie was born on March 13, 1989, in Austin, Texas. Born four weeks prematurely, her birth weight was only 1.219 kilograms (2 pounds, 11 ounces)

“The other kids were scared of me, pointing at me, not wanting to sit with me. I couldn’t process it. I wasn’t doing anything to them, so why was it happening to me? And I didn’t dare tell anyone.” she said (in an interview)

PROGERIA – SOME WORDS ABOUT THE DISEASE

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Progeria is an extremely rare genetic disorder in which symptoms resembling aspects of aging are manifested at a very early age. Progeria is one of several progeroid syndromes.The word progeria comes from the Greek words “pro” (πρό), meaning “before” or “premature”, and “gēras” (γῆρας), meaning “old age”. The disorder has a very low incidence rate, live births.Those born with progeria typically live to their mid teens to early twenties. It is a genetic condition that occurs as a new mutation, and is rarely inherited, as carriers usually do not live to reproduce. Although the term progeria applies strictly speaking to all diseases characterized by premature aging symptoms, and is often used as such, it is often applied specifically in reference to Hutchinson–Gilford progeria syndrome (HGPS).

Scientists are particularly interested in progeria because it might reveal clues about the normal process of aging. Progeria was first described in 1886 by Jonathan Hutchinson. It was also described independently in 1897 by Hastings Gilford. The condition was later named Hutchinson–Gilford progeria syndrome.

 

SIGNS AND SYMPTOMS

Children with progeria usually develop the first symptoms during their first few months of life. The earliest symptoms may include a failure to thrive and a localized scleroderma-like skin condition. As a child ages past infancy, additional conditions become apparent usually around 18–24 months. Limited growth, full-body alopecia (hair loss), and a distinctive appearance (a small face with a shallow recessed jaw, and a pinched nose) are all characteristics of progeria. Signs and symptoms of this progressive disease tend to become more marked as the child ages. Later, the condition causes wrinkled skin, atherosclerosis, kidney failure, loss of eyesight, and cardiovascular problems. Scleroderma, a hardening and tightening of the skin on trunk and extremities of the body, is prevalent. People diagnosed with this disorder usually have small, fragile bodies, like those of elderly people. The face is usually wrinkled, with a larger head in relation to the body, a narrow face and a beak nose. Prominent scalp veins are noticeable (made more obvious by alopecia), as well as prominent eyes. Musculoskeletal degeneration causes loss of body fat and muscle, stiff joints, hip dislocations, and other symptoms generally absent in the non-elderly population. Individuals usually retain typical mental and motor development.

CAUSES

Steps in normal cell Steps in cell with progeria
The gene LMNA encodes a protein called prelamin A.
Prelamin A has a farnesyl group attached to its end.
Farnesyl group is removed from prelamin A. Farnesyl group remains attached to prelamin A.
Normal form is called lamin A. Abnormal form of prelamin A is called progerin.
Lamin A is not anchored to the nuclear rim. Progerin is anchored to the nuclear rim.
Normal state of the nucleus. Abnormally shaped nucleus.

In normal conditions, the LMNA gene codes for a structural protein called prelamin A which undergoes a series of processing steps before becoming its final form, called lamin A.In one of these steps, after prelamin A is made in the cytoplasm, an enzyme called farnesyl transferase attaches a farnesyl functional group to its carboxyl-terminus. The farnesylated prelamin A is then transported through a nuclear pore to the interior of the nucleus. The farnesyl group allows prelamin A to attach temporarily to the nuclear rim. Once the protein is attached, it is cleaved by a protease, thereby removing the farnesyl group along with a few adjacent amino acids. Failure to remove this farnesyl group permanently affixes the protein to the nuclear rim. After cleavage by the protease, prelamin A is referred to as lamin A. Lamin A, along with lamin B and lamin C, makes up the nuclear lamina, which provides structural support to the nucleus.

Before the late 20th century, research on progeria yielded very little information about the syndrome. In 2003, the cause of progeria was discovered to be a point mutation in position 1824 of the LMNA gene, in which cytosine is replaced with thymine.This mutation creates a 5′ cryptic splice site within exon 11, resulting in an abnormally short mature mRNA transcript. This mRNA strand, when translated, yields an abnormal variant of the prelamin A protein whose farnesyl group cannot be removed. Because its farnesyl group cannot be removed, this abnormal protein, referred to as progerin, is permanently affixed to the nuclear rim, and therefore does not become part of the nuclear lamina. Without lamin A, the nuclear lamina is unable to provide the nuclear envelope with adequate structural support, causing it to take on an abnormal shape. Since the support that the nuclear lamina normally provides is necessary for the organizing of chromatin during mitosis, weakening of the nuclear lamina limits the ability of the cell to divide.

To date over 1,400 SNPs of LMNA gene are known. They can manifest in changes on mRNA, splicing or protein (e.g. Arg471Cys, Arg482Gln, Arg527Leu,Arg527Cys, Ala529Val) level.

Progerin may also play a role in normal human aging, since its production is activated in typical senescent cells.

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NEW BORN-BABY WITH PROGERIA

Unlike other “accelerated aging diseases” (such as Werner syndrome, Cockayne syndrome or xeroderma pigmentosum), progeria may not be directly caused by defective DNA repair. Because these diseases cause changes in different aspects of aging, but never in every aspect, they are often called “segmental progerias.”

Diagnosis

Diagnosis is suspected according to signs and symptoms, such as skin changes, abnormal growth, and loss of hair. A genetic test for LMNA mutations can confirm the diagnosis of progeria.

Treatment

No treatment has yet proven effective. Most treatment options have focused on reducing complications (such as cardiovascular disease) with coronary artery bypass surgery or low-dose aspirin.

Growth hormone treatment has been attempted. The use of Morpholinos has also been attempted in order to reduce progerin production. Antisense Morpholino oligonucleotides specifically directed against the mutated exon 11–exon 12 junction in the mutated pre-mRNAs were used.

Potential therapeutic targets for the inhibition of progerin farnesylation

A type of anticancer drug, the farnesyltransferase inhibitors (FTIs), has been proposed, but their use has been mostly limited to animal models. A Phase II clinical trial using the FTI lonafarnib began in May 2007. In studies on the cells another anti-cancer drug, rapamycin, caused removal of progerin from the nuclear membrane through autophagy. It has been proved that pravastatin and zoledronate are effective drugs when it comes to the blocking of farnesyl group production.

Farnesyltransferase inhibitors (FTIs) are drugs that inhibit the activity of an enzyme needed in order to make a link between progerin proteins and farnesyl groups. This link generates the permanent attachment of the progerin to the nuclear rim. In progeria, cellular damage can be appreciated because that attachment takes place and the nucleus is not in a normal state. Lonafarnib is an FTI, which means it can avoid this link, so progerin can not remain attached to the nucleus rim and it now has a more normal state.

The delivery of Lonafarnib is not approved by the US Food and Drug Administration (FDA). Therefore, it can only be used in certain clinical trials. Until the treatment of FTIs is implemented in progeria children its effects cannot be known, although its effects on mice seem to be positive.

Pravastatin, traded as Pravachol or Selektine, is included in the family of statins. As well as zoledronate (also known as Zometa and Reclast, which is a bisphosphonate), its utility in HGPS is the prevention of farnesyl group formation, which progerin needs to provoke the disease. Some animal trials have been realized using FTIs or a combination of pravastatin and zoledronate so as to observe whether they are capable of reversing abnormal nuclei.

The results, obtained by blinded electron microscopic analysis and immunofluorescence microscopy, showed that nucleus abnormalities could be reversed in transgenic mice expressing progerin. The reversion was also observed in vivo—cultured cells from human subjects with progeria—due to the action of the pharmacs, which block protein prenylation (transfer of a farnesyl polypeptide to C-terminal cysteine). The authors of that trial add, when it comes to the results, that: “They further suggest that skin biopsy may be useful to determine if protein farnesylation inhibitors are exerting effects in subjects with HGPS in clinical trials”.

Unlike FTIs, pravastatin and zoledronate were approved by the U.S. FDA (in 2006 and 2001 respectively), although they are not sold as a treatment for progeria. Pravastatin is used to decrease cholesterol levels and zoledronate to prevent hypercalcaemia.

Rapamycin, also known as Sirolimus, is a macrolide. There are recent studies concerning rapamycin which conclude that it can minimize the phenotypic effects of progeria fibroblasts. Other observed consequences of its use are: abolishment of nuclear blebbing, degradation of progerin in affected cells and reduction of insoluble progerin aggregates formation. All these results do not come from any clinical trial, although it is believed that the treatment might benefit HGPS patients.

A 2012 clinical trial found that the cancer drug Lonafarnib can improve weight gain and other symptoms of progeria

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Condition OF Lizzie

Velásquez’s condition is an undiagnosed and non-terminal genetic disorder that bears similarities to many other conditions, especially progeria. Medical researchers at the University of Texas Southwestern Medical Center have speculated that it may be a form of neonatal progeroid syndrome, which does not affect Velásquez’s healthy bones, organs, and teeth.The doctor’s said to her parents that there is only 2 other people in this world with this rare disease

Velásquez is medically unable to gain weight, which is a hallmark of her rare disorder.She has never weighed more than 29 kg (64 pounds), and is required to eat many small meals and snacks throughout the day. Additionally, she is blind in her right eye, which began to cloud over when she was 4, and she is vision-impaired in her left eye.

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FAMILY SUPPORT

Finally, I told my parents and they said, “There is nothing wrong with you, you are just smaller than the other kids. You are beautiful and smart and can accomplish anything.”

My parents gave me an incredible foundation and a strong faith in who I am. They loved me in the face of so many unknowns. When I was first born, doctors said they might have to care for me my whole life. But my family surrounded me with the most incredible support system.

As I got older, I knew my syndrome wasn’t going away. It was a hard pill to swallow. I wanted to look like everyone else and blend in, and I couldn’t find a way to make that happen. I couldn’t blame the doctors or my parents, so I blamed myself.

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THE LIFE CHANGING MOMENT

one day at her middle age (17 years) she was looking for music on youtube in 2006 and she saw a familiar thumbnail.It was named as “The uggliest woman on earth” and there were 4 and half million views for the video of her which was posted by an unknown.

She read one and each comments that followed……..

“It would be nice if she give up her life without becoming a mess for the world”and something like that….she was scattered….But now she is wishing to see him and give him flowercard..

“I didn’t want to retaliate — it was a waste of time. I just wanted to prove them wrong. I realized I could use it for the greater good. I went to college, became a motivational speaker and wrote a book.

In 2013, I did a TEDx talk in Austin. Until then I had sort of a following online but this was completely different – it went viral. Sara Hirsh Bordo, who produced the TedWomen event, invited me to lunch to discuss all of the exciting things happening as well as getting to know each other more. She called me a few days later saying she felt like her purpose was to help shine a light on my story by doing a documentary on my life.I told her I didn’t want the documentary to be just another longer version of my TED talk and I don’t want it to be just about me. That was important to me. When you see the film, it is my story, but it’s also everyone’s story. People can relate to being bullied or feeling insecure or being embarrassed by their looks……””unfortunately bullying will never end — ever. It’s a big reminder that there is work to do to ensure others do not feel alone. We have to show them there is light at the end of the tunnel.”

CAREER

Ever since she was dubbed the “World’s Ugliest Woman” in a video posted on YouTube in 2006, when she was 17, Velásquez has spoken out against bullying. In January 2014 she gave a TEDxAustinWomen Talk titled “How Do YOU Define Yourself”and her YouTube videos have received over 54 million views. She is known for her optimism. For National Bullying Prevention Month in 2015, she hosted a social media challenge for Bystander Revolution’s Month of Action.

Her first work, co-authored with her mother, Rita, is a self-published autobiography published in 2010 in English and Spanish.It is called Lizzie Beautiful: The Lizzie Velásquez Story and includes letters Velásquez’s mother wrote to her as a child.

Velásquez has also written two books directed at teenagers, which share personal stories and offer advice. Be Beautiful, Be You (2012) shares her journey “to discover what truly makes us beautiful, and teaches readers to recognize their unique gifts and blessings”.The book is also available in Spanish as Sé bella, sé tú misma (2013). Another book, Choosing Happiness (2014), talks about some of the obstacles Velásquez has faced and how she “learned the importance of choosing to be happy when it’s all too easy to give up”.Both books were published by a Redemptorist publishing house, Liguori Publications.

A documentary film titled A Brave Heart: The Lizzie Velásquez Story premiered at SXSW on March 14, 2015.The movie aired on Lifetime on October 17, 2016.

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There is nothing in the world that stops you…..just think about what you have got in life……..there will be many of lizzies in the world

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“it is my story, but it’s also everyone’s story.”Be the unique in you.LIzzie is just an examble there is more who are suffering like these.Give them respect…..yes of course,kindness is the basic way to success……….